Heart failure & cardiomyopathies
Phenotypic Expression and Clinical Outcomes in Patients With Arrhythmogenic Cardiomyopathies
Authors' conclusion
The comparison of ACM phenotypes demonstrated that patients with right ventricular involvement, such as ARVC and BIV forms, exhibit a higher incidence of life-threatening ventricular arrhythmias. Conversely, ACM forms characterized by left ventricular involvement, such as ALVC and BIV, show a higher incidence of heart failure, heart transplantation, and hot phases.
Study context
- Population
- Patients diagnosed with arrhythmogenic cardiomyopathy (ACM)
- Participants
- 446 patients
- Exposure
- ACM phenotypes: Arrhythmogenic right ventricular cardiomyopathy (ARVC) vs arrhythmogenic left ventricular cardiomyopathy (ALVC) vs BIV
- Outcome
- Outcomes by ACM phenotype
Main finding
As reported in the abstract
Share of patients
- Life-threatening ventricular arrhythmias more frequent with ARVC and BIV vs ALVC
- P < 0.001
- HF, heart transplantation and cardiac death more frequent with BIV vs ALVC and ARVC
- P < 0.001
- Hot phases more frequent with ALVC vs ARVC and BIV
- P = 0.013
Observational data: associations, not effects.
Original publication
Phenotypic Expression and Clinical Outcomes in Patients With Arrhythmogenic Cardiomyopathies. J Am Coll Cardiol. Published 27 February 2024. doi:10.
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