Photon-counting detector computed tomography for the assessment of coronary stents and in-stent restenosis
Authors' conclusion
PCD-CT demonstrated good diagnostic performance for evaluating obstructive ISR using QCA as the reference standard, regardless of stent diameter.
Study context
- Population
- Patients with prior coronary stent implantation undergoing clinically indicated coronary computed tomography angiography (CCTA) with photon-counting detector computed tomography (PCD-CT) and invasive coronary angiography within 90 days, 2023–2024
- Participants
- 171 patients283 stented lesions
- Comparison
- PCD-CT vs invasive quantitative coronary angiography (QCA)
- Outcome
- Diagnostic performance for obstructive in-stent restenosis (ISR) (≥50% diameter stenosis)
Methodological detailsconsecutive patients, blinded assessment
- Consecutive patients
- Blinded assessment
Performance
As reported in the abstract
Obstructive ISR, lesion level
| Test or model | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|
| PCD-CT | 80.0% | 90.4% | 58.2% | 96.4% | 88.9% |
PCD-CT
Sensitivity80.0%
Specificity90.4%
PPV58.2%
NPV96.4%
Accuracy88.9%
Further findings
Diagnostic performance by stent diameter (subgroup)
Sensitivity
Specificity
PPV
NPV
Accuracy
- Diagnostic performance by stent diameter (subgroup) — No significant differences between stent-diameter subgroups
- p=1.00
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Photon-counting detector computed tomography for the assessment of coronary stents and in-stent restenosis. EuroIntervention. Published 6 October 2025. doi:10.
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