Valvular & structural heart disease
Plasma Volume Status Predicting Clinical Outcomes in Patients Undergoing Transcatheter Edge-To-Edge Mitral Valve Repair
Authors' conclusion
Preoperative PVS is a strong independent prognostic marker in patients undergoing M-TEER, correlating with increased risk of mortality and HF hospitalization. PVS may provide valuable clinical insights for patient stratification and management strategies in M-TEER patients.
Study context
- Population
- Patients with mitral regurgitation (MR) undergoing transcatheter edge-to-edge mitral valve repair (M-TEER), classified as functional MR (FMR) or degenerative MR (DMR)patients who underwent M-TEER
- Participants
- 3,763 patients
- Exposure
- high plasma volume status (PVS) group vs low PVS group
- high PVS groupn = 1,882
- low PVS groupn = 1,881reference
Main finding
As reported in the abstract
Cumulative incidence of all-cause mortality, cardiovascular death and HF hospitalization · up to 3 years
All-cause mortality
Cardiovascular death
HF hospitalization
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause death, cardiovascular death and HF hospitalization (multivariate Cox regression) — high PVS group vs low PVS group · all-cause death | 1.02 (1.01–1.03) | P < 0.001 | |
| All-cause death, cardiovascular death and HF hospitalization (multivariate Cox regression) — high PVS group vs low PVS group · cardiovascular death | 1.02 (1.01–1.03) | P < 0.001 | |
| All-cause death, cardiovascular death and HF hospitalization (multivariate Cox regression) — high PVS group vs low PVS group · HF hospitalization | 1.02 (1.01–1.02) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
All-cause mortality, cardiovascular death and heart failure (HF) hospitalization in FMR and DMR cohorts
- Similar trends observed in the FMR and DMR cohorts
- all P < 0.05
- Independent association of high PVS with all-cause death, cardiovascular death and HF hospitalization in FMR and DMR sub-groups
- all P < 0.05
Reduction of MR severity to moderate or less after M-TEER
- Associated with improved outcomes in both the high and low PVS groups
Original publication
Plasma Volume Status Predicting Clinical Outcomes in Patients Undergoing Transcatheter Edge-To-Edge Mitral Valve Repair. ESC Heart Fail. Published 17 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it