Valvular & structural heart disease
Correlates and prognostic value of left atrial strain in transcatheter edge-to-edge repair for degenerative mitral regurgitation
Authors' conclusion
Although unrelated to procedural feasibility, safety, or efficacy, worse LAS identifies higher-risk patients prone to experience a less favourable clinical course post-TEER for degenerative MR.
Study context
- Population
- Individuals referred to isolated, first-time transcatheter edge-to-edge repair (TEER) for degenerative mitral regurgitation (MR)median age 82 years, 62.4% male
- Participants
- 367 individuals
- Exposure
- Stratified by median LAS at baseline and at 1-month post-procedure
- Outcome
- Baseline characteristics
- Follow-up
- Preprocedural
Main finding
As reported in the abstract
- Subjects with below-median preprocedural LAS presented more often with acute heart failure (HF) and/or haemodynamic instability, displayed higher interventional risk and atrial fibrillation/flutter prevalence, and had more pronounced chamber dysfunction/dilatation
Observational data: associations, not effects.
Further findings
Procedural features
- Technical success rate in both groups
- >97%
- Freedom from above-moderate MR or New York Heart Association Class III-IV in both groups
- >80%
- Procedural features were unaffected by baseline LAS allocation
Deaths and/or HF hospitalizations · first post-interventional year
- Worse baseline LAS was associated with higher rates, cumulative incidences, and risks of deaths and/or HF hospitalizations
Excess composite risk (exploratory analysis)
- Hazard ratio
- 2.16
- 95% confidence interval
- 1.16-4.00
- P
- P = 0.015
- Exploratory analysis
- Confined to stable, chronic HF cases with significant left atrial (LA) dilatation
One-month post-procedural LAS · 1 month post-procedure
- One-month post-procedural LAS directly correlated with its baseline counterpart
- A more impaired value-rather than the change in LAS-conferred heightened deaths/HF readmissions risk
Original publication
Correlates and prognostic value of left atrial strain in transcatheter edge-to-edge repair for degenerative mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 11 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it