Coronary disease & ACSCohort study
Polygenic prediction of coronary heart disease among 130 000 Mexican adults
- Prospective cohort study
Authors' conclusion
In this Mexican population, existing PRSs predicted CHD independently of established vascular risk factors, particularly for men.
Study context
- Population
- Adults aged 35–79 years, Mexico City Prospective Study (67% women; mean age 51 ± 12 years; Indigenous American ancestry averaged 67%)5,163 coronary heart disease (CHD) cases (3.9%)
- Participants
- 133,207 adults
- Exposure
- CHD polygenic risk scores (PRSs)
- Outcome
- CHD (self-reported prior heart attack or angina, or CHD death before age 80 years)
Main finding
As reported in the abstract
CHD per 1 SD PRS increase (8 PRSs)
OR per 1 SD PRS increase, lowest of eight PRSs
1.05 (95% CI, 1.03-1.08)
OR per 1 SD PRS increase, highest of eight PRSs
1.29 (95% CI, 1.25-1.33)
Observational data: associations, not effects.
Further findings
CHD, by sex (subgroup)
- For six PRSs, associations substantially stronger in men than women
CHD, by age and ancestry (subgroup)
- Associations consistent across strata of age and ancestry
PRS type
- Multi-ancestry PRSs outperformed Eurocentric-ancestry PRSs
C-statistic
- Adding a PRS to a risk model did not increase the C-statistic noticeably
Original publication
Polygenic prediction of coronary heart disease among 130 000 Mexican adults. Eur J Prev Cardiol. Published 13 November 2025. doi:10.1093/eurjpc/zwaf728
Summarised from the published abstract; every number is checked against it