Polygenic risk score, dietary inflammatory potential, and incident coronary heart disease
Main finding · Incident CHD, joint effect of PRS and EDIPResult — go to the resultHazard ratio 3.87 95% CI 2.74–5.46Authors' conclusion
High dietary inflammatory potential was associated with a higher CHD risk, especially in those with high PRS
Study context
- Population
- British UK Biobank participants who completed the 24-h dietary assessment at baseline1,346 incident coronary heart disease (CHD) cases
- Participants
- 51,889 participants
- Exposure
- High vs low dietary inflammatory potential and polygenic risk score (PRS) for CHD, jointly
- Outcome
- Incident CHD
- Follow-up
- Median 11 years
Methodological detailsUK Biobank, empirical dietary inflammatory pattern (EDIP) score by reduced rank regression and stepwise linear regression; PRS from 1.7 million genetic variants
- UK Biobank
- EDIP score by reduced rank regression and stepwise linear regression; PRS from 1.7 million genetic variants
Main finding
Incident CHD, joint effect of PRS and EDIP
Hazard ratio
3.87
95% CI 2.74–5.46
High PRS (Q5) + high EDIP (T3) vs Low PRS (Q1) + low EDIP (T1)
HR 3.87 (95% CI 2.74–5.46)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident CHD by EDIP score | 1.26 (1.10–1.45) | |
| 0.512Hazard ratio (log scale) |
Incident CHD risk gradient across PRS categories
| Comparison | HR (95% CI) | |
|---|---|---|
| Low PRS (Q1) | 1.12 (0.73–1.71) | |
| Intermediate PRS (Q2-4) | 1.20 (1.01–1.43) | |
| High PRS (Q5) | 1.42 (1.10–1.83) | |
| 0.512Hazard ratio (log scale) |
Original publication
Polygenic risk score, dietary inflammatory potential, and incident coronary heart disease. Eur J Prev Cardiol. Published 30 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it