Polygenic Risk for Cardiometabolic and Cardiovascular Disease in a Multiethnic Cohort of Breast Cancer Survivors
Authors' conclusion
Although there may be potential value of PGS in predicting the risk for CMD and CVD events in women with histories of breast cancer, current PGS performance is limited.
Study context
- Population
- Women with histories of breast cancer (breast cancer survivors)27 polygenic scores (PGS), 12 outcomes
- Participants
- 3,620 women
- Exposure
- PGS-added or combined models vs clinical covariates-only models
- Outcome
- Performance of PGS for CVD-related traits to predict incident cardiometabolic disorder (CMD) and CVD
Methodological detailsmultiethnic
- Multiethnic
Main finding
As reported in the abstract
- Significant associations between PGS and cardiometabolic disorder (CMD) or cardiovascular disease (CVD) events after Bonferroni correction
- 23
Observational data: associations, not effects.
Further findings
PGS performance by cardiotoxic cancer treatment
- For some outcomes, PGS performed worse among patients who received cardiotoxic cancer treatments
Original publication
Polygenic Risk for Cardiometabolic and Cardiovascular Disease in a Multiethnic Cohort of Breast Cancer Survivors. JACC CardioOncol. Published February 2026. doi:10.
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