Coronary disease & ACSCohort study
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque
- Prospective cohort study
- serial coronary computed tomography angiography (CTA)
- AI-based plaque quantification
Authors' conclusion
Polygenic risk is strongly associated with future long-term plaque progression and HRP in patients suspected of having CAD.
Study context
- Population
- Patients suspected of having coronary artery disease (CAD) with CAD polygenic risk score (PRS) measurement and serial coronary CTA
- Participants
- 288 patients
- Exposure
- High vs low CAD polygenic risk score
- Outcome
- Change in percent atheroma volume (PAV), percent noncalcified plaque progression and high-risk plaque (HRP) prevalence
- Follow-up
- Median scan interval 10.2 years
Main finding
As reported in the abstract
PAV progression · per 10 years of follow-up
1 SD increase in CAD PRS associated with increase in percent atheroma volume (PAV) progression (multivariable adjusted)
0.69%
Observational data: associations, not effects.
Further findings
Baseline PAV
P < 0.001
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| HRP · baseline | 2.85 (1.14–7.14) | P = 0.026 | |
| HRP · follow-up | 6.16 (2.55–14.91) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Discrimination of above-median noncalcified plaque progression
- AUC, conventional risk factors + CAD PRS vs conventional risk factors alone
- 0.73 vs 0.69; P = 0.039
Original publication
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque. JACC Cardiovasc Imaging. Published 14 August 2024. doi:10.1016/j.jcmg.2024.06.015
Summarised from the published abstract; every number is checked against it