Increased incidence of adverse events in diabetes mellitus patients with combined multiple vulnerable plaque features: new insights from the COMBINE OCT-FFR trial
Primary resultResult — go to the resultHazard ratio 10.10 95% CI 3.37–30.25Authors' conclusion
In patients with DM and non-ischaemic lesions, TCFA, h-PB, r-MLA, and CP were predictors of adverse events. However, the presence of two or more OCT-VFs significantly increased the likelihood of MACE at 5 years.
Study context
- Population
- Patients with diabetes mellitus (DM) having ≥1 non-ischaemic lesions (FFR > 0.80) undergoing systematic OCT
- Comparison
- Patients with combined OCT-VFs vs without OCT-VFs
- Primary endpoint
- MACE:
- Cardiac mortality
- Target vessel MI
- Clinically driven target lesion revascularization
- Hospitalization for unstable angina
- Follow-up
- Up to 5 years
Methodological detailsprospective, double-blind, international
- Prospective
- Double-blind
- International
Primary result
As reported in the abstract
Hazard ratio
10.10
95% CI 3.37–30.25
P < 0.001
By group
h-PB + r-MLA + CP + TCFA vs No OCT-VFs
HR 10.10 (95% CI 3.37–30.25); P < 0.001
Further findings
Prevalence of OCT-VFs
- Thin-cap fibroatheroma (TCFA)
- 98 (25.1%)
- Reduced minimal lumen area (r-MLA)
- 159 (40.8%)
- High plaque burden (h-PB)
- 56 (14.4%)
- Complicated plaque (CP)
- 116 (29.8%)
Original publication
Increased incidence of adverse events in diabetes mellitus patients with combined multiple vulnerable plaque features: new insights from the COMBINE OCT-FFR trial. Eur Heart J Cardiovasc Imaging. Published 14 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it