Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery: A VISION Substudy
Main finding · Association of type II diabetes (T2D) PRS with MINSResult — go to the resultOdds ratio 1.26 95% CI 1.00–1.58Authors' conclusion
The T2D PRS and the HbA1c PRS were associated with an increased risk of MINS. The findings may reflect the multifactorial pathophysiology of MINS. Larger genetic studies and trials evaluating perioperative glucose management warrant consideration.
Study context
- Population
- Patients aged 45 and above who underwent noncardiac surgery253 MINS cases matched with 253 controls
- Participants
- 506 patients
- Comparison
- Association between each polygenic risk scores (PRS) and MINS
- MINS casesn = 253
- Controlsn = 253
- Outcome
- Association of type II diabetes (T2D) PRS with MINS
Methodological detailsmatched, adjusted for age, sex, limited to individuals of European ancestry
- Matched
- Adjusted for age, sex
- Limited to individuals of European ancestry
Main finding
As reported in the abstract
Odds ratio
1.26
95% CI 1.00–1.58
P = 0.047
T2D PRS
OR 1.26 (95% CI 1.00–1.58); P = 0.047
Observational data: associations, not effects.
Further findings
Association of HbA1c PRS with MINS
| OR (95% CI) | P value | ||
|---|---|---|---|
| HbA1c PRS | 1.26 (1.03–1.54) | P = 0.026 | |
| 0.512Odds ratio (log scale) |
Other PRS, including coronary artery disease, stroke, and lipid biomarkers
- No significant associations
Original publication
Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery: A VISION Substudy. JACC Adv. Published 26 March 2025. doi:10.
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