Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial
Authors' conclusion
In this single-center trial, self-monitoring and physician-guided titration of antihypertensive medications was associated with lower blood pressure during the first 9 months postpartum than usual postnatal outpatient care in the UK.
Study context
- Population
- Women aged ≥18 years after pregnancy complicated by preeclampsia or gestational hypertension, requiring antihypertensive medication at postnatal discharge; single UK hospital200 (91%) in primary analysis
- Participants
- 220 women
- Comparison
- Self-monitoring with physician-optimized antihypertensive titration vs usual postnatal care
- Interventionn = 112
- Controln = 108reference
- Primary endpoint
- 24-hour mean diastolic BP, adjusted for baseline postnatal BP
- Follow-up
- 9 months postpartum
Methodological detailsopen-label, blinded end point, single-centre
- Open-label
- Blinded end point
- Single-centre
Primary result
As reported in the abstract
24-h mean DBP, adjusted for baseline postnatal BP · 249 (16) days postpartum
Difference
5.8 mm Hg
By group
- Between-group difference −5.80 mm Hg
- −5.80 (95% CI, −7.40 to −4.20; P < .001)
Further findings
24-h mean SBP · lower with Intervention
difference 6.5
- 24-h mean SBP — Between-group difference −6.51 mm Hg
- −6.51 (95% CI, −8.80 to −4.22; P < .001)
Original publication
Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial. JAMA. Published 28 November 2023. doi:10.
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