Post-diagnostic statin use and its association with cancer recurrence and mortality in breast cancer patients: a systematic review and meta-analysis
Pooled result · Breast cancer recurrenceResult — go to the resultHazard ratio 0.76 95% CI 0.67–0.87Authors' conclusion
Among patients with breast cancer, statin use post-diagnosis decreases the risk of breast cancer recurrence and breast cancer mortality. Furthermore, lipophilic statins exhibit an additional advantage of reduction in all-cause mortality.
Study context
- Population
- Patients with breast cancer
- Participants
- 156,448 patients15 studies
- Comparison
- Post-diagnostic statin use vs no statin use
- Outcome
- Breast cancer recurrence
Methodological detailsrandom-effect model, Search of PubMed, Embase and Scopus from inception to 30 May 2023
- Random-effect model
- Search of PubMed, Embase and Scopus from inception to 30 May 2023
Pooled result
As reported in the abstract
Hazard ratio
0.76
95% CI 0.67–0.87
Statin usersvs Non-statin users
HR 0.76 (95% CI 0.67–0.87)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| Breast cancer recurrence, by statin type (subgroup)Statin usersvs Non-statin usersLipophilic statins | 0.73 (0.63–0.85) | |
| Breast cancer recurrence, by statin type (subgroup)Statin usersvs Non-statin usersHydrophilic statins | 1.17 (0.82–1.68) | |
| Breast cancer mortalityStatin usersvs Non-statin usersAll statins | 0.80 (0.66–0.96) | |
| Breast cancer mortalityStatin usersvs Non-statin usersLipophilic statins | 0.85 (0.74–0.99) | |
| All-cause mortalityStatin usersvs Non-statin usersAll statins | 0.82 (0.66–1.02) | |
| All-cause mortalityStatin usersvs Non-statin usersLipophilic statins | 0.84 (0.75–0.93) | |
| 0.512Hazard ratio (log scale) |
Original publication
Post-diagnostic statin use and its association with cancer recurrence and mortality in breast cancer patients: a systematic review and meta-analysis. Eur Heart J Cardiovasc Pharmacother. Published 10 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →