Cardio-oncology & otherCohort study
Sex-Specific Differences in Myocardial Injury Incidence after COVID-19 mRNA-1273 Booster Vaccination
- Prospective cohort study
- matched controls
Authors' conclusion
mRNA-1273 vaccine-associated myocardial injury was more common than previously thought, being mild and transient, and more frequent in women versus men.
Study context
- Population
- Hospital employees scheduled for COVID-19 mRNA-1273 booster vaccinationmedian age 37 years
- Participants
- 777 employees
- Exposure
- mRNA-1273 booster recipients vs matched controls
- Boostern = 777
- Matched controlsn = 777reference
- Outcome
- mRNA-1273 vaccination-associated myocardial injury: acute dynamic hs-cTnT increase above sex-specific upper limit of normal without alternative cause
- Follow-up
- Day 3 (48-96 h) after vaccination
Main finding
As reported in the abstract
mRNA-1273 vaccine-associated myocardial injury (adjudicated) · day 3 (48-96 h)
Participants with adjudicated vaccine-associated myocardial injury
22 (2.8% [95% CI 1.7-4.3%])
Observational data: associations, not effects.
Further findings
hs-cTnT concentration · day 3 · significantly higher in booster cohort
P < 0.001
- Vaccine-associated myocardial injury, by sex: Women 3.7% (95% CI 2.3–5.7%)
- Vaccine-associated myocardial injury, by sex: Men 0.8% (95% CI 0.1–3.0%)
- High-sensitivity cardiac troponin T (hs-cTnT) concentration: matched controls n = 777
Reactogenicity, antibodies and cytokines in cases vs persons without myocardial injury
- Comparable systemic reactogenicity, anti-IL-1RA, anti-NP, anti-S1 and systemic inflammation markers; lower interferon (IFN)-λ1 (IL-29) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in cases
Safety
ECG changes and MACE within 30 days
- Patients with ECG changes
- 0
- MACE within 30 days
- 0% [95% CI 0-0.4%]
- hs-cTnT elevations mild and only temporary
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex-Specific Differences in Myocardial Injury Incidence after COVID-19 mRNA-1273 Booster Vaccination. Eur J Heart Fail. Published 9 August 2023. doi:10.1002/ejhf.2978
Summarised from the published abstract; every number is checked against it