Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV
Authors' conclusion
PTSD is independently associated with ED in WWH. Whether treatment for PTSD improves ED and CVD in WWH needs further study.
Study context
- Population
- Women from the Women's Interagency HIV Study in Atlanta, Georgia, who reported previous traumawomen enrolled
- Participants
- 87 women
- Comparison
- The impact of posttraumatic stress disorder (PTSD), HIV, and their interaction on endothelial function
- PTSDn = 24
- HIVn = 55
- Outcome
- HIV and PTSD prevalence
Main finding
As reported in the abstract
Had HIV
55
63.2%
Had PTSD
24
27.5%
Had both
13
14.9%
Further findings
| Outcome | PTSD | Without PTSD | Estimate | P value |
|---|---|---|---|---|
| SmokingPTSD vs without PTSD · more likely with PTSD | 75% | 44.4% | P = 0.02 | |
| Depressive symptomsPTSD vs without PTSD · more likely with PTSD | 58.3% | 28.6% | P = 0.02 | |
| FMD in WWHPTSD severity · lower FMD in WWH · independently associated | β per 10-point increase −0.72% (95% CI −1.22 to −0.21) | P = 0.01 | ||
| FMD in WWHPTSD status · lower FMD in WWH · independently associated | β −2.51% (95% CI −4.21 to −0.77) | P = 0.01 |
HIV-PTSD interaction effect on flow-mediated dilation (FMD)
- HIV-PTSD (severity and status) interaction effect on FMD significant
- P = 0.01
- Adjusted models
FMD in women with HIV (WWH)
- Not associated in those without HIV
Original publication
Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV. JACC Adv. Published 19 January 2025. doi:10.
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