Acute cardiac care & resuscitation
Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest
Authors' conclusion
Of the comatose patients admitted to ICU after cardiac arrest, one in five experienced a potassium disorder on ICU admission. Hyperkalaemia was associated with unfavourable functional outcomes at 180 days, while hypokalaemia was not.
Study context
- Population
- Comatose patients admitted to intensive care unit (ICU) after return of spontaneous circulation (ROSC) following cardiac arrest
- Participants
- 1,133 patients4 RCTs
- Comparison
- Hyperkalaemia or hypokalaemia vs normokalaemia at ICU admission
- Normokalaemian = 877reference
- Hypokalaemian = 35
- Hyperkalaemian = 221
- Primary endpoint
- Unfavourable functional outcome (cerebral performance category 3 to 5)
- Follow-up
- 180 days
Methodological detailsmixed effects logistic regression
- Mixed effects logistic regression
Primary result
As reported in the abstract
Unfavourable functional outcome
Each group vs normokalaemiaEstimate (95 % CI)P value
Hyperkalaemia
adjusted OR 1.85(1.10–3.12)
P = 0.02Hypokalaemia
OR 1.36(0.51–3.60)
P = 0.53Further findings
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| Unfavourable functional outcome, adjusted for modified cardiac arrest hospital prognosis score (subgroup, n = 833) · 180 daysHyperkalaemiavs NormokalaemiaAssociations not significant | 1.74 (0.91–3.34) | P = 0.10 | |
| Unfavourable functional outcome, adjusted for modified cardiac arrest hospital prognosis score (subgroup, n = 833) · 180 daysHypokalaemiavs NormokalaemiaAssociations not significant | 1.48 (0.40–5.44) | P = 0.55 | |
| 0.20.5125Odds ratio (log scale) |
%
| Outcome | Hypokalaemia | Hyperkalaemia |
|---|---|---|
| Prevalence of potassium disorders at ICU admission | 3.1 | 19.5 |
Original publication
Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest. Resuscitation. Published 20 November 2024. doi:10.
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