Arrhythmias & electrophysiology
Power-law properties of nocturnal arrhythmia avalanches: A novel marker for incident cardiovascular events
Authors' conclusion
The NAA power-law exponent is a reproducible, predictive marker for incident CV events and mortality.
Study context
- Population
- Participants with nocturnal electrocardiographic (ECG) recordings from Sleep Heart Health Study (SHHS), MrOS and Multi-Ethnic Study of Atherosclerosis (MESA)SHHS, MrOS and MESA
- Participants
- 9,176 participants
- Outcome
- Association of NAA power-law exponent (α) with MACE and mortality
Methodological detailspooled analysis of SHHS, MrOS and MESA cohorts
- Pooled analysis of SHHS, MrOS and MESA cohorts
Main finding
As reported in the abstract
Hazard ratio (CI)P value
SHHSCV mortality
1.39(1.07–1.79)
P = 0.012MrOSCV mortality
1.42(1.02–1.94)
P = 0.039MESACV events
3.46(1.46–8.21)
P = 0.005Observational data: associations, not effects.
Further findings
Fit of NAA episode distribution to power law (positive log likelihood ratio)
vs exponential
vs log-normal
Fit of nocturnal arrhythmia avalanche (NAA) episode distribution to power law (positive log likelihood ratio)
- Consistent with power law vs comparator distributions in all datasets
Original publication
Power-law properties of nocturnal arrhythmia avalanches: A novel marker for incident cardiovascular events. Heart Rhythm. Published 8 August 2024. doi:10.
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