Heart failure & cardiomyopathies
Predicting 1-Year Heart Failure Hospitalization and Mortality Post-Discharge from the Intensive Cardiac Care Unit
Authors' conclusion
The ICCU-HF score showed good performance in predicting the 1-year risk of unplanned HF hospitalization and death in a large cohort of unselected patients admitted to the ICCU, with excellent results in the validation cohort. This score effectively stratifies patients into risk groups, enhancing its utility in clinical decision-making.
Study context
- Population
- All consecutive patients admitted to the intensive cardiac care unit (ICCUs) in 39 French centres from 7 to 22 April 2021patients in training and validation cohorts · training cohort (21 centres) 1,008 · validation cohort (eight centres) 463
- Participants
- 1,471 patients
- Comparison
- ICCU-HF score vs NT-proBNP for predicting the primary composite outcome
- Outcome
- Unplanned hospitalization for heart failure (HF) and cardiovascular death
- Follow-up
- 1-year after discharge
Methodological detailsdevelopment and validation of a risk score, consecutive patients, 39 French centres, least absolute shrinkage and selection operator (LASSO) regression
- Development and validation of a risk score
- Consecutive patients
- 39 French centres
- LASSO regression
Performance
As reported in the abstract
Patients who experienced the primary outcome
99
6.7%
Further findings
| Outcome | Values | HR (95% CI) | P value | |
|---|---|---|---|---|
| Composite outcome by risk group — intermediate-risk group vs low-risk group | 4.09 (2.23–7.50) | P < 0.001 | ||
| Composite outcome by risk group — high-risk group vs low-risk group | 12.69 (7.02–22.95) | P < 0.001 | ||
| 0.050.21520Hazard ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| Discrimination: ICCU-HF score vs NT-proBNP · score outperformed NT-proBNP | ICCU-HF score AUC 0.77 (95% CI 0.71–0.83) · NT-proBNP AUC 0.72 (95% CI 0.66–0.79) | P = 0.008 |
Predictors identified by LASSO
- Left ventricular ejection fraction, significant valvular disease grade 2+, Killip score >1, NT-proBNP, creatinine level, previous ventricular arrhythmia and use of inotropes during hospitalization
- seven predictors
Discrimination in the validation cohort
- AUC
- 0.83 (95% CI: 0.77-0.89)
Original publication
Predicting 1-Year Heart Failure Hospitalization and Mortality Post-Discharge from the Intensive Cardiac Care Unit. ESC Heart Fail. Published 21 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it