Heart failure & cardiomyopathies
Prognostic Impact of Plasma Volume Status During Hospital Admission in Patients with Acute Decompensated Heart Failure
Authors' conclusion
This study highlights the effect of PVS measured at different timepoints on the prognoses of ADHF patients.
Study context
- Population
- Patients with acute decompensated heart failure (ADHF) admitted to the cardiovascular intensive care unit (CICU), Nippon Medical School Hospital, 2018–2020; excluding RBC transfusion, dialysis, discharge from CICU or in-hospital deathof 363 consecutive patients
- Participants
- 206 patients
- Exposure
- Plasma volume status (PVS) quartiles
- Outcome
- All-cause mortality
- Follow-up
- Observation period 1134 days
Methodological detailssingle-centre, consecutive patients, PVS measured at admission, transfer to general ward (GW) and discharge by Kaplan-Hakim formula
- Single-centre
- Consecutive patients
- PVS measured at admission, transfer to GW and discharge by Kaplan-Hakim formula
Main finding
As reported in the abstract
All-cause mortality by PVS quartile (Kaplan-Meier)
- High PVS group had significantly higher mortality at admission, transfer to GW and discharge than other groups
- High PVS vs Other PVS groups: P = 0.016
- High PVS vs Other PVS groups: P = 0.005
- High PVS vs Other PVS groups: P < 0.001
Observational data: associations, not effects.
Further findings
PVS at discharge as independent prognostic factor (multivariate analysis)
| Comparison | HR (CI) | P value | |
|---|---|---|---|
| PVS at discharge · independent poor prognostic factor · multivariate analysis | 1.06 (1.00–1.12) | P = 0.048 | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic Impact of Plasma Volume Status During Hospital Admission in Patients with Acute Decompensated Heart Failure. ESC Heart Fail. Published 28 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it