Predicting Adverse Cardiac Events After Radiotherapy for Locally Advanced Non–Small Cell Lung Cancer
Authors' conclusion
Adverse cardiac events associated with radiation occur in more than 20% of patients undergoing thoracic radiotherapy within a median time of <2 years. The present findings provide further evidence to support significant associations between TotalLeft radiotherapy dose and cardiac events and define CAC as a predictive risk factor.
Study context
- Population
- Patients with locally advanced non-small cell lung cancer treated with radiotherapy (2006–2018)
- Participants
- 233 patients
- Outcome
- Grade ≥3 adverse cardiac events; associations with cardiac substructure dose and CAC scores
Main finding
As reported in the abstract
Grade ≥3 cardiac events
Hazard ratio (95% CI)P value
TotalLeft volume receiving 15 Gy (per 1 cc)
1.38(1.11–1.72)
P = 0.004CAC score >5
2.51(1.08–5.86)
P = 0.033Per 1 cc, as printed
- Cardiac events after radiotherapy
- 22.3%
- Median time to cardiac event
- 21.5 months (range: 1.7-118.9 months)
Observational data: associations, not effects.
Further findings
Cardiac event incidence by risk model (age, TotalLeft CAC >5, volume receiving 15 Gy)
P < 0.001
Visual vs automated coronary artery calcium (CAC) scoring correlation
- R
- 0.72; P < 0.001
Original publication
Predicting Adverse Cardiac Events After Radiotherapy for Locally Advanced Non–Small Cell Lung Cancer. JACC CardioOncol. Published 4 October 2023. doi:10.
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