Heart failure & cardiomyopathies
Predicting Right Ventricular Failure After Left Ventricular Assist Device Implant: A Novel Approach
Authors' conclusion
Distinct, potentially predictable phenogroups of patients who have significantly different long-term outcomes exist within consensus-defined post-LVAD RVF populations.
Study context
- Population
- Patients after left ventricular assist device (LVAD) implantpatients identified · 'no RVF' 67 · 'provisional RVF' 165
- Participants
- 232 patients
- Predictors
- Pre-implant metrics; top predictors including renal function, liver function, heart rate and pre-LVAD right ventricular (RV) function
- Predicted outcome
- post-implant RVF phenogroup ('early RVF' population phenogroup clusters)
Methodological detailselectronic health records queries
- Electronic health records queries
Model performance
As reported in the abstract
AUROC
Prediction of phenogroup clusters from the 'early RVF' population
0.84
Further findings
'Early RVF' time window: 'well' vs 'sick' phenogroup clusters
- Renal function differed
- P < 0.001
- Hepatic function differed
- P = 0.013
- RV assist device (RVAD) usage differed
- P = 0.001
- 1 year mortality differed
- P = 0.047
- Similar RV function and pulmonary vasodilator usage during the first month after LVAD
- Also differed in heart failure therapy tolerance
'Late RVF' time window: 'well' vs 'sick' phenogroup clusters
- RV function similar
- P = 0.111
- RVAD proportions similar
- P = 0.757
- Pulmonary vasodilator usage differed
- P = 0.001
- 1 year mortality differed
- P < 0.001
- Also differed in heart failure medication tolerance
Original publication
Predicting Right Ventricular Failure After Left Ventricular Assist Device Implant: A Novel Approach. ESC Heart Fail. Published 20 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →