Heart failure & cardiomyopathies
Left atrial strain analysis improves left ventricular filling pressures non-invasive estimation in the acute phase of Takotsubo syndrome
Authors' conclusion
In our study, lower LA reservoir and pump strain values were better predictors of LVEDP as compared with traditional echocardiographic indexes in the acute phase of TTS syndrome. Moreover, LA reservoir strain was an independent predictor of adverse in-hospital outcomes.
Study context
- Population
- Patients in the acute phase of Takotsubo syndrome; TTE within 48 h of admission, left ventricular and diastolic pressure (LVEDP) measured at catheterizationanalysed
- Participants
- 62 patients
- Exposure
- Left atrial (LA) strain vs traditional echocardiographic indexes for estimating LVEDP
- Outcome
- Ability of LA strain to estimate LVEDP non-invasively vs traditional echocardiographic indexes
- Follow-up
- Acute phase (TTE within 48 h from admission)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
LVEDP above mean
AUC
0.909
95% CI 0.818–0.999P < 0.001
LA reservoir strain
AUC
0.889
95% CI 0.789–0.988P < 0.001
LA pump strain
LA reservoir strain
- R with LVEDP
- −0.859
- AUC (LVEDP above mean)
- 0.909
LA pump strain
- R with LVEDP
- −0.848
- AUC (LVEDP above mean)
- 0.889
R with LVEDP
LA reservoir strain−0.859
LA pump strain−0.848
AUC (LVEDP above mean)
LA reservoir strain0.909
LA pump strain0.889
Observational data: associations, not effects.
Further findings
Mean LVEDP
- Mean LVEDP
- 24.53 ± 7.92 mmHg
In-hospital complications (acute HF, all-cause death, life-threatening arrhythmias)
- In-hospital complications
- 25 (40.3%)
- LA reservoir strain independent predictor of worse in-hospital outcomes, with LVEDP and LVEF
- all P < 0.001
Original publication
Left atrial strain analysis improves left ventricular filling pressures non-invasive estimation in the acute phase of Takotsubo syndrome. Eur Heart J Cardiovasc Imaging. Published 27 March 2023. doi:10.
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