Arrhythmias & electrophysiology
Prediction of major arrhythmic outcomes in ischaemic cardiomyopathy: value of hibernating myocardium in positron emission tomography/computed tomography
Main finding · MAEResult — go to the resultHazard ratio 0.31 95% CI 0.1–0.8Authors' conclusion
HM conveys a lower risk of MAE in patients with ICM.
Study context
- Population
- Consecutive patients with ischaemic cardiomyopathy undergoing combined NH3- and FDG-PET/CT
- Participants
- 254 patients
- Exposure
- Large hibernating myocardium (HM) vs no or small HM on NH3/FDG PET/CT
- Outcome
- Major arrhythmic events (MAEs) [sudden cardiac death, implantable cardioverter defibrillator (ICD) therapy, and sustained ventricular tachycardia/fibrillation]
- Follow-up
- Median 5.4 (IQR 2.2-9.5) years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
MAE · median 5.4 years
Hazard ratio
0.31
95% CI 0.1–0.8
P = 0.001
Large HMvs No HM
HR 0.31 (95% CI 0.1–0.8); P = 0.001
As reported in the abstract
- MAE occurred in 34 patients overall
- 13%
- Large HM remained significantly associated with lower MAE after adjustment for prior MAE, left ventricular ejection fraction (LVEF) ≤35% and scar ≥10%
- P = 0.016
Observational data: associations, not effects.
Further findings
LVEF change over time
- LVEF improved with large HM
- P = 0.006
- No change without HM
- P = 0.610
- No change with small HM
- P = 0.240
PET/CT findings
- Ischaemia
- 94 (37%)
- Scar
- 229 (90%)
- HM
- 195 (77%)
Original publication
Prediction of major arrhythmic outcomes in ischaemic cardiomyopathy: value of hibernating myocardium in positron emission tomography/computed tomography. Eur Heart J Cardiovasc Imaging. Published 30 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →