Arrhythmias & electrophysiology
Predictive value of notched P wave for life-threatening arrhythmias in patients with Brugada syndrome: Insights from a multicenter prospective study
Authors' conclusion
A notched P wave on a standard 12-lead ECG independently predicts life-threatening arrhythmias in BrS and may improve risk stratification by complementing conventional predictors.
Study context
- Population
- Patients with Brugada syndrome (BrS) (mean age 51 ± 14 years; 95% men)patients with BrS
- Participants
- 510 patients
- Exposure
- Patients with notched P waves vs those without
- Notched P wavesn = 52
- Outcome
- Cardiac events:
- VF
- Sustained ventricular tachycardia
- Sudden cardiac death
- Follow-up
- Mean 107 ± 62 months
Methodological detailsprospective multicenter registry across 61 hospitals in Japan
- Prospective multicenter registry across 61 hospitals in Japan
Main finding
As reported in the abstract
P < 0.001
- Patients experiencing cardiac events, overall
- 58 patients (11%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Event-free survival (Kaplan-Meier)Lower event-free survival in patients with notched P waves | P < 0.001 |
Cardiac events, multivariable Cox regression
- Notched P wave, independent predictor: hazard ratio
- 2.63; 95% confidence interval 1.35-4.78; P = .006
- History of ventricular fibrillation (VF) also an independent predictor
- Multivariable
Original publication
Predictive value of notched P wave for life-threatening arrhythmias in patients with Brugada syndrome: Insights from a multicenter prospective study. Heart Rhythm. Published 10 March 2026. doi:10.
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