Arrhythmias & electrophysiology
Predictive value of sudden cardiac death risk stratification for outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy
Authors' conclusion
M-HR of SCD in HCM was associated with a higher recurrence rate after CA of AF.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) who underwent catheter ablation (CA) of atrial fibrillation (AF), classified by the HCM risk-SCD modelincluded of 417 patients with HCM screened among 23,904 patients who underwent CA of AF
- Participants
- 339 patients
- Comparison
- Long-term outcomes were compared between the groups.
- Low-risk (LR) groupn = 292reference
- Medium- to high-risk (M-HR) groupn = 47
- Outcome
- Recurrence rate after a single procedure
- Follow-up
- Median 43.0 months (12.0-69.0)
Main finding
As reported in the abstract
P < 0.001
Further findings
Recurrence rate after the last ablation · higher in the M-HR group
P < 0.001
Cardiac death · During follow-up · no significant difference
P = 0.995
Heart failure hospitalization · During follow-up · no significant difference
P = 0.471
Stroke · During follow-up · no significant difference
P = 0.071
| Outcome | Hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Recurrence (multivariate analysis)M-HR of SCD was an independent predictor of recurrence · multivariate analysis | 1.77 (1.14–2.74) | P = 0.010 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Predictive value of sudden cardiac death risk stratification for outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy. Heart Rhythm. Published 22 July 2025. doi:10.
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