Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score
Authors' conclusion
Fibrinogen levels, age, platelet count, and the presence of ICH and CVT were significantly associated with mortality in patients with TTS, and the FAPIC score comprising these risk factors could predict mortality.
Study context
- Population
- Patients with thrombosis with thrombocytopenia syndrome (TTS) after ChAdOx1 nCoV-19 vaccination6 case series · 13 case reports
- Participants
- 64 patients
- Outcome
- Mortality (predictors and FAPIC score)
Methodological detailsprognostic score development, internal validation (cross-validation, bootstrapping), external validation
- Prognostic score development
- Internal validation (cross-validation, bootstrapping)
- External validation
Pooled result
As reported in the abstract
Mortality
- Overall mortality
- 35.9% (23/64)
- FAPIC score C-statistic
- 0.837 (95% CI 0.732-0.942)
- Expected mortality, FAPIC 0
- 2.08%
- Expected mortality, FAPIC 1
- 6.66%
- Expected mortality, FAPIC 2
- 19.31%
- Expected mortality, FAPIC 3
- 44.54%
- Expected mortality, FAPIC 4
- 72.94%
- Expected mortality, FAPIC 5
- 90.05%
Original publication
Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score. Eur Heart J. Published 21 September 2021. doi:10.
Summarised from the published abstract; every number is checked against it