Valvular & structural heart diseaseMeta-analysis
Predictors of Procedural and Clinical Outcomes Following Transcatheter Tricuspid Edge-to-Edge Repair
- Systematic review and meta-analysis
- random-effects meta-analysis
- PRISMA 2020-compliant
PubMed, Scopus, Cochrane Library and Google Scholar searched January 2008 to March 2025
Authors' conclusion
Limited data suggest that an intermediate disease profile may derive the greatest benefit, but this finding is confined to single-registry analyses.
Study context
- Population
- Patients undergoing tricuspid transcatheter edge-to-edge repair59 studies
- Outcome
- Multivariable predictors of procedural success and adverse outcomes (mortality, HF hospitalization, MACE, procedural success)
Pooled result
As reported in the abstract
- Baseline tricuspid regurgitation severity predicted residual tricuspid regurgitation
- OR 2.50 (95% CI 1.33-4.71)
- Nonanteroseptal jet location predicted residual tricuspid regurgitation
- OR 2.46 (95% CI 1.08-5.60)
- Increasing coaptation gap predicted residual tricuspid regurgitation
- HR per mm 1.19 (95% CI 1.07-1.33)
- Residual tricuspid regurgitation ≥3+ and all-cause mortality
- pooled HR 2.19 (95% CI 1.60-3.00; I2 = 0%-2%)
- Residual tricuspid regurgitation ≥3+ and MACE
- pooled HR 1.84 (95% CI 1.37-2.48; I2 = 0%-2%)
Further pooled results
Surgical risk models
- EuroSCORE II showed limited discrimination; TRI-SCORE performed better
Original publication
Predictors of Procedural and Clinical Outcomes Following Transcatheter Tricuspid Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 25 May 2026. doi:10.1016/j.jcin.2026.03.017
Summarised from the published abstract; every number is checked against it