Pregnancy-Associated Myocardial Infarction in Alberta: A Population-Based Study
Authors' conclusion
PAMI is an increasing cause of maternal morbidity and mortality in Alberta. Clinicians should have a high index of suspicion for PAMI and ensure optimal management of this dangerous complication of pregnancy.
Study context
- Population
- Women with confirmed pregnancy-associated myocardial infarction (MI) in Alberta, Canada (2003–2017)cases of PAMI
- Participants
- 43 women
- Outcome
- Crude incidence of PAMI
- Follow-up
- 2003-2017
Methodological details15-year, provincial administrative database, validated algorithm, medical record review, linkage with a provincial coronary heart disease registry
- 15-year
- Provincial administrative database
- Validated algorithm
- Medical record review
- Linkage with a provincial coronary heart disease registry
Main finding
As reported in the abstract
Crude incidence
∼5.64/100,000 births
Observational data: associations, not effects.
Further findings
Timing of MI
- Antepartum
- 16.3%
- Antepartum mean gestational age
- 18 weeks
- Peripartum
- 30.2%
- Within 6 months postpartum
- 53.4%
- Postpartum mean time after delivery
- 7.8 weeks
Mechanism of PAMI
- Spontaneous coronary artery dissection (most common; predominated postpartum)
- 44.2%
- Coronary artery disease was a frequent antepartum cause of MI
- Demand ischemia was the leading cause of peripartum MI
Maternal mortality
- Maternal mortality
- ≈9%
Original publication
Pregnancy-Associated Myocardial Infarction in Alberta: A Population-Based Study. JACC Adv. Published 8 January 2025. doi:10.
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