Heart failure & cardiomyopathies
Premature Ventricular Contraction Location and Incident Heart Failure
Authors' conclusion
In a large population-based cohort, ventricular ectopy was most frequently localized to the left ventricle. Individuals with ectopy arising from the left ventricle and from epicardial locations experienced a higher likelihood of incident heart failure compared with those without PVCs or those with PVCs from other locations.
Study context
- Population
- Ambulatory adults without prevalent HF in the CHS and ARIC cohorts427 (2.1%) with premature ventricular contraction (PVC)
- Participants
- 20,590 adults
- Exposure
- PVC on baseline electrocardiogram (ECG), by anatomical location, vs no PVC
- Outcome
- Incident HF
- Follow-up
- Mean 19.2 years
Methodological detailspopulation-based, pooled CHS and ARIC cohorts, PVC location assessed by 2 expert reviewers from baseline 12-lead ECG morphology
- Population-based
- Pooled CHS and ARIC cohorts
- PVC location assessed by 2 expert reviewers from baseline 12-lead ECG morphology
Main finding
As reported in the abstract
Incident HF (adjusted)
Hazard ratio (95% CI)P value
PVCvs No PVCany PVC
1.43(1.20–1.70)
P < 0.001Epicardiumvs No PVC
2.98(1.12–7.95)
P = 0.029LVvs No PVC
1.59(1.30–1.94)
P < 0.001Observational data: associations, not effects.
Further findings
PVC site of origin (among participants with PVC)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Premature Ventricular Contraction Location and Incident Heart Failure. JACC Clin Electrophysiol. Published 17 September 2025. doi:10.
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