Heart failure & cardiomyopathies
Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy: A Cross-Sectional Study
Authors' conclusion
We found no evidence that the PVC burden alone is an independent predictor of cardiomyopathy.
Study context
- Population
- Patients with ≥24 hours of ambulatory monitoring, a PVC burden of ≥5%, and a transthoracic echocardiogram within 3 months of monitoringincluded sample, 746 with a transthoracic echocardiogram
- Participants
- 1,451 patients
- Exposure
- Association of PVC burden with depressed left ventricular ejection fraction (LVEF)
- Outcome
- Baseline characteristics and PVC burden
Methodological detailstreatment-agnostic
- Treatment-agnostic
Main finding
As reported in the abstract
Age
68.2 ± 14.5 years
Female sex
39.6%
Average PVC burden
12.4% ± 7.4%
5%–43.4%
Observational data: associations, not effects.
Further findings
LVEF among subjects with a transthoracic echocardiogram
- Subjects with a transthoracic echocardiogram
- 746
- Mean LVEF
- 55.6% ± 9.2% (25%-76.8%)
- Of the 746 with echocardiogram, subjects with LVEF <50%
- 171 subjects (22.9%)
Association between percentage of premature ventricular complexes (PVCs) and LVEF
- No significant association
- P = 0.78
- Unadjusted and adjusted analyses
Association between PVC burden and depressed left ventricular function
- No significant association
- P = 0.13
- Unadjusted and adjusted analyses
Original publication
Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy: A Cross-Sectional Study. JACC Clin Electrophysiol. Published 12 February 2025. doi:10.
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