Prenatal and Postnatal Ambient Air Pollution and Kawasaki Disease: A Systematic Review and Meta-Analysis
Pooled result · KD after short-term postnatal exposure to PM2.5Result — go to the resultOdds ratio 1.011 95% CI 1.003–1.019Authors' conclusion
Both prenatal and postnatal exposure to several ambient pollutants are associated with the risk of KD.
Study context
- Population
- Studies investigating the effects of ambient air pollution on Kawasaki disease (KD)
- Participants
- 124,857 participants13 studies
- Comparison
- Pooled ORs for an increase in ambient air pollutant concentration of 10 μg/m³
- Outcome
- KD after short-term postnatal exposure to PM2.5
Methodological detailsfixed- or random-effects model
- Fixed- or random-effects model
Pooled result
As reported in the abstract
Odds ratio
1.011
95% CI 1.003–1.019
Per 10 μg/m³ increase in PM2.5
OR 1.011 (95% CI 1.003–1.019)
Per 10 μg/m³ increase in PM2.5, as printed
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| KD after short-term postnatal exposure to PM10I2 = 38%; high-quality evidence | 1.004 (1.000–1.008) | |
| KD after long-term postnatal exposure to PM2.5I2 = 41%; high-quality evidence | 1.415 (1.179–1.697) | |
| 0.512Odds ratio (log scale) |
KD occurrence with other pollutant exposures
- Prenatal exposure to carbon monoxide, nitric oxide, nitrogen oxides, and sulfur dioxide; short-term postnatal exposure to nitric oxide; and long-term postnatal exposure to carbon monoxide and nitrogen oxides were also associated with KD occurrence
Risk of bias
- Studies at high risk of bias
- Seven studies
Original publication
Prenatal and Postnatal Ambient Air Pollution and Kawasaki Disease: A Systematic Review and Meta-Analysis. JACC Adv. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →