The presence or absence of standard modifiable cardiovascular risk factors in patients with myocardial infarction impacts long-term but not 30-day mortality: a UK Biobank prospective cohort study
Authors' conclusion
In this population-based cohort, SMuRF status significantly impacted long-term but not short-term mortality following MI, indicating early survival is predominantly driven by acute-phase factors rather than baseline cardiovascular risk profiles.
Study context
- Population
- UK Biobank participants with incident myocardial infarction (MI), 2006–2022MI cases of 487,177
- Participants
- 15,463 participants
- Exposure
- SMuRF-absence vs SMuRFs present in patients with MI
- SMuRF-absencen = 1,034
- Outcome
- CV mortality after MI
- Follow-up
- 30 days
Methodological detailspopulation-based, UK Biobank, propensity-score matched analysis
- Population-based
- UK Biobank
- Propensity-score matched analysis
Main finding
As reported in the abstract
30-day mortality
SMuRF-absence vs SMuRF-presenceHazard ratio (95% CI)P value
Adjusted Cox model
0.82(0.65–1.04)
P = 0.103Propensity score-matched
0.95(0.69–1.29)
P = 0.729Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Long-term mortality · 10 years post-MISMuRF-absencevs SMuRF-presenceLogistic regression | 0.61 (0.49–0.75) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
30-day mortality by period, sex, age, socioeconomic status
- No significant effect modification by sex, age, socioeconomic status or period of MI occurrence
Original publication
The presence or absence of standard modifiable cardiovascular risk factors in patients with myocardial infarction impacts long-term but not 30-day mortality: a UK Biobank prospective cohort study. Eur J Prev Cardiol. Published 6 June 2025. doi:10.
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