Valvular & structural heart disease
Prevalence, aetiology, and outcomes of native pulmonary regurgitation in the general adult population
Authors' conclusion
Moderate or severe PR had a lower prevalence vs. TR. The most frequent cause was pulmonary hypertension for ≥moderate PR and congenital/iatrogenic for severe PR. Mortality in patients with acquired ≥moderate PR appeared to be related to the underlying cause, with no excess mortality compared with matched patients without PR. Whether specifically severe PR confers excess mortality requires future investigation.
Study context
- Population
- Adult residents of Olmsted County who had clinically indicated echocardiography 2004–2023 at Mayo Clinic, Rochester, and had moderate or severe pulmonary regurgitation (PR)adults with moderate or severe PR, 61 (51%) had severe PR
- Participants
- 398 residents
- Exposure
- Pulmonary hypertension-related and isolated idiopathic PR vs. propensity-matched patients without PR
- Outcome
- Age- and sex-adjusted US prevalence of moderate/severe PR
Methodological detailscommunity setting, propensity-matched comparison
- Community setting
- Propensity-matched comparison
Main finding
As reported in the abstract
Moderate/severe PR
0.11%
≥moderate tricuspid regurgitation
0.67%
Observational data: associations, not effects.
Further findings
Per 100 person-year
| Outcome | Primary (mostly carcinoid) PR | Pulmonary hypertension-related PR | Isolated idiopathic PR |
|---|---|---|---|
| All-cause mortality rate per 100 person-year | 73 | 16 | 6 |
Cause of moderate/severe PR
- Pulmonary hypertension
- 77%
- Congenital/iatrogenic
- 11%
- Primary pulmonary valve disease
- 2%
- Of primary pulmonary valve disease, due to carcinoid
- 88%
- Idiopathic isolated
- 10%
Cause of severe PR
- Congenital/iatrogenic disease
- 52%
- Pulmonary hypertension
- 39%
- Primary PR
- 5%
- Isolated idiopathic
- 3%
All-cause mortality rate per 100 person-year
- Pulmonary hypertension-related PR not different vs. propensity-matched patients without PR
- Isolated idiopathic PR not different vs. matched patients without PR
Baseline characteristics
- Median age
- 77 years
- Females
- 48%
- Severe PR
- 61 (51%)
Original publication
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