Heart failure & cardiomyopathies
Prevalence and clinical outcomes of isolated or combined moderate to severe mitral and tricuspid regurgitation in patients with cardiac amyloidosis
Authors' conclusion
In a large cohort of patients with CA, MR, and TR were common. Isolated TR and combined MR/TR were associated with worse prognosis regardless of CA aetiology, LV, and RV function, with TR carrying the highest risk.
Study context
- Population
- Patients with cardiac amyloidosis (ATTR or AL)ATTR n = 359
- Participants
- 538 patients
- Exposure
- Isolated mitral regurgitation (MR), isolated tricuspid regurgitation (TR) or combined MR/TR vs no significant MR/TR
- No significant MR/TRn = 240reference
- Isolated MRn = 112
- Isolated TRn = 66
- Combined MR/TRn = 120
- Outcome
- All-cause death or worsening HF events
Methodological detailsmulticentre, three Italian referral centres
- Multicentre
- Three Italian referral centres
Main finding
As reported in the abstract
Prevalence of MR/TR
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (CI) | |
|---|---|---|
| All-cause death or worsening HF eventsIsolated TRvs No significant MR/TR | 2.75 (1.78–4.24) | |
| All-cause death or worsening HF eventsCombined MR/TRvs No significant MR/TR | 2.31 (1.44–3.70) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- All-cause death or worsening HF events: adjusted for age, sex, cardiac amyloidosis (CA) subtypes, laboratory and echocardiographic markers of CA severity
Original publication
Prevalence and clinical outcomes of isolated or combined moderate to severe mitral and tricuspid regurgitation in patients with cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. Published 18 March 2024. doi:10.
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