Heart failure & cardiomyopathies
Waitlist Outcomes for Pediatric Heart Transplantation in the Current Era: An Analysis of the Pediatric Heart Transplant Society Database
Authors' conclusion
There is significant variability in WM among status-1A patients.
Study context
- Population
- Patients <18 years listed for heart transplantation, Pediatric Heart Transplant Society database, 2010–2021
- Participants
- 5,974 patients
- Exposure
- Status 1A vs Status 1B vs Status 2 vs Status 7
- Status 1An = 3,928
- Status 1Bn = 1,012
- Status 2n = 963
- Status 7n = 65
- Outcome
- Waitlist mortality (WM): death while awaiting transplant or removal from the waitlist due to clinical deterioration
- Follow-up
- First 12 months on the list
Methodological detailsregistry database analysis
- Registry database analysis
Main finding
As reported in the abstract
Risk factors for WM in status 1A
- Smaller size and lower eGFR associated with higher waitlist mortality (WM)
- No congenital heart disease or ventricular assist device (VAD) support at listing associated with decreased WM
- Smallest size cohort: cardiac diagnoses other than dilated cardiomyopathy were risk factors for WM
- Previous cardiac surgery a risk factor in the 0.3 to 0.7 m² and >0.7 m² body surface area (BSA) groups
- VAD support associated with lower WM except in single ventricle cohort (higher WM)
- ECMO and mechanical ventilation associated with increased WM in all cohorts
- Further analysis performed in only status 1A patients
Observational data: associations, not effects.
Original publication
Waitlist Outcomes for Pediatric Heart Transplantation in the Current Era: An Analysis of the Pediatric Heart Transplant Society Database. Circulation. Published 28 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →