Valvular & structural heart disease
Prevalence and predictors of mitral annular disjunction and ventricular ectopy in mitral valve prolapse
Authors' conclusion
MAD in MVP is associated with bileaflet or myxomatous MVP, absence of hypertension, T-wave inversion, and female sex. There is increased cfVE and mortality with MAD
Study context
- Population
- Adults with mitral valve prolapse (MVP) on transthoracic echocardiography, University of North Carolina Medical Center, 2016–2019
- Participants
- 632 adults
- Exposure
- Mitral annular disjunction (MAD) vs no MAD in MVP
- MADn = 94
- Outcome
- Predictors of complex or frequent ventricular ectopy (cfVE); risk of cfVE and mortality with MAD
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prevalence of MAD
MAD
14.9%
94
Observational data: associations, not effects.
Further findings
Independent associations of MAD
| OR (95% CI) | P value | ||
|---|---|---|---|
| Bileaflet prolapse | 4.25 (2.47–7.33) | P < 0.0001 | |
| Myxomatous valve | 2.17 (1.27–3.71) | P = 0.005 | |
| Absence of hypertension | 2.00 (1.21–3.32) | P = 0.007 | |
| ECG inferior or lateral lead T-wave inversion | 2.07 (1.23–3.48) | P = 0.006 | |
| Female sex | 1.99 (1.21–3.25) | P = 0.006 | |
| 0.10.31310Odds ratio (log scale) |
cfVE
P < 0.0001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Independent cfVE predictorsMADvs Without MAD | 2.23 (1.47–3.36) | P = 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
Independent cfVE predictors
| HR (95% CI) | P value | ||
|---|---|---|---|
| Bileaflet prolapse | 1.86 (1.25–2.76) | P = 0.002 | |
| HF | 1.79 (1.16–2.77) | P = 0.009 | |
| Lower LVEF | 0.14 (0.03–0.61) | P = 0.009 | |
| CAD | 1.60 (1.05–2.43) | P = 0.03 | |
| Inferior or lateral lead T-wave inversion | 1.51 (1.03–2.22) | P = 0.03 | |
| 0.050.21520Hazard ratio (log scale) |
Mortality · median 40 (33-48) months
- Increased mortality with MAD
- P = 0.04
Original publication
Prevalence and predictors of mitral annular disjunction and ventricular ectopy in mitral valve prolapse. Heart Rhythm. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →