Valvular & structural heart disease
Prevalence and prognostic role of atrial fibrillation in chronic severe aortic regurgitation
Authors' conclusion
AF is present in one in six patients with chronic≥moderate-to-severe AR and is associated with an increased risk of mortality even after adjusting for measures of LV systolic and diastolic function.
Study context
- Population
- Adults with chronic ≥moderate-to-severe aortic regurgitation (AR), March 2004 to April 2019; acute AR, ≥moderate other valve disease or prior valve surgery excluded
- Participants
- 1,006 adults
- Exposure
- Atrial fibrillation (AF) vs no AF
- AFn = 161
- Outcome
- All-cause mortality
- Follow-up
- Median 1.6 years (IQR 0.2-6.2)
Methodological detailspropensity matching
- Propensity matching
Main finding
As reported in the abstract
AF vs No AFHazard ratio (95% CI)
Multivariable model 1 (age, NYHA II-IV, Charlson index, LV end-systolic volume index, AF)
1.61(1.07–2.43)
Model 2 (+ left atrial volume index)
2.21(1.31–3.72)
Model 3 (+ systolic pulmonary artery pressure)
2.06(1.21–3.52)
After propensity matching
1.58(1.01–2.48)
Observational data: associations, not effects.
Further findings
- Prevalence of AF at ≥moderate-to-severe AR diagnosis
- 16% · 161
Original publication
Prevalence and prognostic role of atrial fibrillation in chronic severe aortic regurgitation. Heart. Published 16 July 2025. doi:10.
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