Valvular & structural heart disease
Prevalence and Prognostic Significance of Frailty in Elderly Patients With Severe Valvular Heart Diseases
Main finding · All-cause deathResult — go to the resultAdjusted hazard ratio 1.50 95% CI 1.25–1.81Authors' conclusion
Frailty is highly prevalent and independently associated with poor prognosis in severe VHD. The simplified 4-item frailty score offers a practical and incrementally valuable tool for enhancing risk stratification in routine clinical practice.
Study context
- Population
- Elderly patients with severe valvular heart disease (VHD)elderly patients with severe VHD from the China-DVD2 Study
- Participants
- 2,147 patients
- Comparison
- Association between frailty and adverse clinical events; frailty score added to the European System for Cardiac Operative Risk Evaluation II
- Outcome
- All-cause death
- Follow-up
- 1-year
Main finding
All-cause death
Adjusted hazard ratio
1.50
95% CI 1.25–1.81
As reported in the abstract
Secondary outcomes
All-cause death and heart failure hospitalization (secondary composite outcome) · 1-year
| Comparison | Adjusted HR (95% CI) | |
|---|---|---|
| Simplified frailty score · composite outcome | 1.53 (1.32–1.77) | |
| 0.512Adjusted hazard ratio (log scale) |
Frailty and prefrailty prevalence
- Frailty prevalence, depending on the assessment tool
- 16.8% to 39.3%
- Prefrailty prevalence, depending on the assessment tool
- 50.9% to 64.5%
Exploratory subgroups and specific VHD subtypes
- These associations were preserved across the exploratory subgroups and specific VHD subtypes
C-statistic, all-cause mortality: frailty score added to European System for Cardiac Operative Risk Evaluation II
- C-statistic
- 0.715 vs 0.668
- Likelihood ratio test P < 0.001
C-statistic, composite outcome: frailty score added to European System for Cardiac Operative Risk Evaluation II
- C-statistic
- 0.722 vs 0.688
- Likelihood ratio test P < 0.001
Original publication
Summarised from the published abstract; every number is checked against it