Valvular & structural heart disease
Prevalence and Prognostic Significance of Malnutrition Risk in Patients With Valvular Heart Disease
Authors' conclusion
Malnutrition risk was prevalent in various VHDs and was strongly associated with increased mortality and MACEs. The GNRI score provided incremental prognostic information for clinical outcomes.
Study context
- Population
- Patients with moderate or severe valvular heart disease in the China-VHD Study
- Participants
- 8,908 patients
- Exposure
- Moderate or severe malnutrition risk vs no malnutrition risk
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Methodological detailsChina-VHD Study
- China-VHD Study
Main finding
As reported in the abstract
2-year all-cause mortality by malnutrition risk (GNRI)
- Moderate or severe malnutrition risk vs none: significantly higher risk of all-cause death in various valvular heart disease (VHDs)
- all P < 0.02
- Strongest association in tricuspid regurgitation: mortality HR 3.18 (95% CI 1.99 to 5.10)
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
2-year MACE by malnutrition risk (geriatric nutritional risk index (GNRI))
- Moderate or severe malnutrition risk vs none: significantly higher risk of MACE in various VHDs
- all P < 0.02
- Strongest association in tricuspid regurgitation: MACE HR 2.33 (95% CI 1.58 to 3.44)
- P < 0.001
Incremental prediction of adding GNRI to EuroSCORE
- Improved risk stratification and outcome prediction (C-statistic)
- P < 0.001
- Likelihood ratio test
- P < 0.001
Original publication
Prevalence and Prognostic Significance of Malnutrition Risk in Patients With Valvular Heart Disease. JACC Adv. Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →