Arrhythmias & electrophysiology
Prevalence of glucose metabolism disorders and its association with left atrial remodelling before and after catheter ablation in patients with atrial fibrillation
Authors' conclusion
Approximately 65% of patients with AF who underwent their first CA had abnormal glucose metabolism. Patients with DM had significantly impaired LA function compared with non-DM patients. Impaired glucose tolerance/IFG as well as DM carries significant risk of unfavourable LA reverse remodelling.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing first catheter ablation157 without known diabetes mellitus (DM) had OGTT
- Participants
- 204 patients
- Exposure
- Normal glucose tolerance (NGT) vs impaired glucose tolerance (IGT)/impaired fasting glucose (IFG) vs DM
- Outcome
- Prevalence of glucose metabolism disorders (OGTT in patients without known DM)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Abnormal glucose metabolism, all patients
65.2%
OGTT-identified abnormal glucose metabolism (11 new DM, 74 IGT, 1 IFG)
86
Observational data: associations, not effects.
Further findings
LA reverse remodelling (≥15% decrease in LA volume index) · 6 months after CA — NGT vs IGT/IFG and DM
P = 0.006
Baseline left atrial (LA) function (LA reservoir strain, LA stiffness) · before catheter ablation (CA)
- DM had worst LA reservoir strain and LA stiffness
- both P < 0.05
- No significant difference in baseline LA parameters between NGT and IGT/IFG
LA reverse remodelling (≥15% decrease in LA volume index) · 6 months after CA
- DM and IFG/IGT carry significant risk of lack of LA reverse remodelling independent of baseline LA size and AF recurrence
Original publication
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