Outcomes of newly diagnosed atrial fibrillation in patients with acute coronary syndromes
Authors' conclusion
Newly diagnosed AF in ACS patients was associated with higher rates of MACE and ischaemic stroke compared to ACS patients without or with known AF. Among the ACS patients with new AF, an episode lasting >24 hours was associated with worse outcomes than shorter episodes, while post-CABG occurrence of AF showed relatively better outcomes compared to spontaneously occurring AF.
Study context
- Population
- Patients with confirmed acute coronary syndrome (ACS)
- Participants
- 4,433 patients
- Exposure
- Newly diagnosed atrial fibrillation (AF) vs known AF vs no AF in ACS
- No AFn = 3,598reference
- Newly diagnosed AFn = 438
- Known AFn = 397
- Outcome
- MACE
- Follow-up
- 1 year
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Each group vs no AFHazard ratio (95% CI)
Newly diagnosed AF
1.52(1.19–1.90)
Known AF
0.93(0.70–1.23)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| MACE, new AF episode >24 hvs <24 h (subgroup) | 1.99 (1.36–2.93) | |
| MACE, new AF post-CABGvs spontaneous (subgroup) | 0.52 (0.31–0.86) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Newly diagnosed AF | Known AF |
|---|---|---|
| OAC at discharge | 53.4% | 89.2% |
Oral anticoagulants (OAC) at discharge
- OAC rates higher in new AF subcategories with higher major adverse cardiovascular events (MACE) and ischaemic stroke rates
Original publication
Outcomes of newly diagnosed atrial fibrillation in patients with acute coronary syndromes. EuroIntervention. Published 19 August 2024. doi:10.
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