Prevalence of left atrial thrombus in patients with atrial flutter in comparison to atrial fibrillation

Wybraniec, MT; Wesołek, F; Szyszka, P; Cichoń, M; Orszulak, M; Mizia-Szubryt, M; Wita, M; Gawałko, M; Budnik, M; Uziębło-Życzkowska, B; Krzesiński, P; Starzyk, K; Wożakowska-Kapłon, B; Daniłowicz-Szymanowicz, L; Kaufmann, D; Wójcik, M; Błaszczyk, R; Hiczkiewicz, J; Budzianowski, J; Łojewska, K; Kosmalska, K; Fijałkowski, M; Szymańska, A; Wiktorska, A; Haberka, M; Michalski, B; Kupczyńska, K; Tomaszuk-Kazberuk, A; Wilk-Śledziewska, K; Wachnicka-Truty, R; Koziński, M; Burchardt, P; Mizia-Stec, K; Kapłon-Cieślicka, A

doi:10.1016/j.hrthm.2025.03.1980

Prevalence of left atrial thrombus in patients with atrial flutter in comparison to atrial fibrillation

Heart RhythmPublished 25 Mar 2025subanalysis of a multicenter, prospective Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) registry

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Authors' conclusion

The risk of thrombus formation in AFL seems to be similar to that in AF, supporting similar recommendations concerning OAC use.

Study context

Population: Atrial fibrillation (AF) and atrial flutter (AFL) patients referred for ablation or electrical cardioversion regardless of oral anticoagulation (OAC) use
Participants: 3,109 participants

Exposure: Patients with AFL in comparison to AF according to anticoagulation status
AFLn = 532
AFn = 2,577
Outcome: Left atrial thrombus (LAT) presence on preprocedural transesophageal echocardiography

Main finding

As reported in the abstract

AF8.3%

AFL6.8%

P = 0.235

Observational data: associations, not effects.

Further findings

Therapeutic OAC use (anticoagulation lasting at least 3 weeks)

P < 0.001

AF89.8%

AFL82.5%

LAT in patients receiving therapeutic OAC

P = 0.167

AF7.6%

AFL5.7%

LAT in patients without therapeutic OAC

P = 0.459

AF14.9%

AFL11.8%

Reference

Authors: Wybraniec MT, Wesołek F, Szyszka P, Cichoń M, Orszulak M, Mizia-Szubryt M, et al.
All 34 authors
Wybraniec MT, Wesołek F, Szyszka P, Cichoń M, Orszulak M, Mizia-Szubryt M, Wita M, Gawałko M, Budnik M, Uziębło-Życzkowska B, Krzesiński P, Starzyk K, Wożakowska-Kapłon B, Daniłowicz-Szymanowicz L, Kaufmann D, Wójcik M, Błaszczyk R, Hiczkiewicz J, Budzianowski J, Łojewska K, Kosmalska K, Fijałkowski M, Szymańska A, Wiktorska A, Haberka M, Michalski B, Kupczyńska K, Tomaszuk-Kazberuk A, Wilk-Śledziewska K, Wachnicka-Truty R, Koziński M, Burchardt P, Mizia-Stec K, Kapłon-Cieślicka A
Journal: Heart Rhythm
Published: 25 Mar 2025
DOI: 10.1016/j.hrthm.2025.03.1980
PubMed: 40147725

Topic: Arrhythmias & electrophysiology

Exposure definitions

AF: atrial fibrillation
AFL: Atrial flutter

Key notes

Regardless of therapeutic OAC use

Original publication

Prevalence of left atrial thrombus in patients with atrial flutter in comparison to atrial fibrillation. Heart Rhythm. Published 25 March 2025. doi:10.1016/j.hrthm.2025.03.1980

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