Arrhythmias & electrophysiology
SCAI/HRS technical review on transcatheter left atrial appendage occlusion
Authors' conclusion
Left atrial appendage occlusion is an effective alternative to OAC for stroke prevention in NVAF patients with bleeding risks, but uncertainties remain regarding imaging strategies and postprocedural management.
Study context
- Population
- Adults with nonvalvular atrial fibrillation (NVAF) undergoing left atrial appendage occlusion (LAAO), or with peridevice leak or device-related thrombus after occlusion27 studies
- Comparison
- Percutaneous LAAO vs oral anticoagulation (OAC) or no therapy, and across preprocedure imaging, intraprocedure guidance and postprocedure antithrombotic approaches
- Outcome
- Outcomes of LAAO for stroke prevention in NVAF (vs OAC, vs no therapy; preprocedure imaging, intraprocedure guidance, postprocedure antithrombotic regimens)
Methodological detailsnarrative synthesis, GRADE certainty assessment, Searched PubMed, Embase and Cochrane Library through January 5, 2024; 3769 titles and abstracts screened
- Narrative synthesis
- GRADE certainty assessment
- Searched PubMed, Embase and Cochrane Library through January 5, 2024; 3769 titles and abstracts screened
Pooled result
As reported in the abstract
- 27 studies met eligibility criteria and contributed data to the analysis
Further pooled results
Imaging strategies and postprocedural management
- Uncertainties remain
Original publication
SCAI/HRS technical review on transcatheter left atrial appendage occlusion. Heart Rhythm. Published 5 August 2025. doi:10.
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