Heart failure & cardiomyopathies
Prevalence of Transthyretin Cardiac Amyloidosis in Undifferentiated Heart Failure with Preserved Ejection Fraction
Authors' conclusion
In an undifferentiated HFpEF cohort, 8% were found to have wild-type ATTR-CM using a DPD scintigraphy-based screening protocol.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) (ejection fraction (EF) ≥50%) aged ≥60 years, no prior evaluation for cardiac amyloidosis or known monoclonal gammopathy
- Participants
- 86 patients
- Exposure
- DPD scintigraphy-positive vs DPD scintigraphy-negative
- DPD-positiven = 7
- Outcome
- Prevalence of ATTR-CM by DPD scintigraphy-based screening
Methodological detailsregional cardiology network
- Regional cardiology network
Main finding
As reported in the abstract
Prevalence of wild-type ATTR-CM
DPD-positive
8%
7
Observational data: associations, not effects.
Further findings
Age
Male sex
P = 0.02
LV wall thickness
P = 0.002
High-sensitivity troponin at diagnosis
P < 0.001
Original publication
Prevalence of Transthyretin Cardiac Amyloidosis in Undifferentiated Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 7 November 2024. doi:10.
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