Valvular & structural heart disease
Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications
Main finding · Composite of sudden arrhythmic death, HF hospitalization or new-onset AFResult — go to the resultHazard ratio 6.09 95% CI 1.69–21.9Authors' conclusion
In a large MVP registry, bileaflet involvement is associated with reduced LA function regardless of MR severity, suggesting a primary atriopathy in this MVP subtype. Abnormal LA function, particularly when assessed through a multiparametric approach, is linked to a higher risk of cardiovascular events
Study context
- Population
- Consecutive patients with mitral valve prolapse (MVP) and no prior AF
- Participants
- 334 patients
- Exposure
- Left atrial (LA) remodeling stages; bileaflet MVP vs other MVP subtypes
- Outcome
- Composite of:
- Sudden arrhythmic death
- HF hospitalization
- New-onset AF
Methodological detailsconsecutive patients, registry
- Consecutive patients
- Registry
Main finding
As reported in the abstract
Hazard ratio
6.09
95% CI 1.69–21.9
P = 0.006
Stage 4vs Stage 1
HR 6.09 (95% CI 1.69–21.9); P = 0.006
- Risk of events increased with lower LA reservoir strain and higher LA remodeling stage
- P < 0.001
Observational data: associations, not effects.
Further findings
LA function, bileaflet MVP with no or mild mitral regurgitation (MR) vs other MVP subtypes
- Lower LA reservoir strain in bileaflet MVP
- P = 0.04
- Lower LA function index in bileaflet MVP
- P < 0.001
- Bileaflet MVP associated with lower LA function parameters after adjustment for CV risk factors and MR ≥moderate
- all P<0.05
- Multivariable linear regression
Original publication
Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications. Circ Cardiovasc Imaging. Published 11 June 2024. doi:10.
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