Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease
Authors' conclusion
In women with ANOCA, a high circulating proCNP concentration is associated with a distinct cardiovascular risk profile beyond pro-inflammatory biomarkers and an increased risk of all-cause mortality.
Study context
- Population
- Women with angina pectoris but no obstructive coronary artery disease (ANOCA)women in baseline/follow-up analyses · baseline/follow-up analyses 1,508 · PLS analyses 1,598
- Participants
- 1,508 women
- Exposure
- High proCNP concentration and outcome
- High proCNPn = 223
- Outcome
- Baseline associations of high proCNP
Main finding
As reported in the abstract
- Hypertension
- P = 0.001
- Diabetes mellitus
- P < 0.001
- Postmenopausal status
- P < 0.001
- Not age
- P = 0.13
Observational data: associations, not effects.
Further findings
All-cause mortality
| HRadjusted (95% CI) | P value | ||
|---|---|---|---|
| High proCNPAdjusted (age, creatinine) | 1.57 (0.99–2.49) | P = 0.06 | |
| 0.512HRadjusted (log scale) |
Composite endpoint of cardiovascular events
| HRadjusted (95% CI) | P value | ||
|---|---|---|---|
| High proCNPAdjusted (age, creatinine) | 1.03 (0.68–1.56) | P = 0.90 | |
| 0.512HRadjusted (log scale) |
| Outcome | HRcrude (95% CI) | P value |
|---|---|---|
| All-cause mortalityHigh proCNP | 1.73 (1.10–2.73) | P = 0.02 |
| Composite endpoint of cardiovascular eventsHigh proCNP | 1.08 (0.72–1.62) | P = 0.71 |
Exploratory PLS analyses with 185 cardiovascular plasma markers
- proCNP positively associated with atherosclerotic markers and negatively associated with pro-inflammatory markers
- Exploratory
Original publication
Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease. JACC Adv. Published 6 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →