Coronary disease & ACSSecondary analysis
Probabilities of treatment effects in complete or culprit-only revascularization for non-ST-elevation myocardial infarction (NSTEMI): A Bayesian re-analysis of the SLIM trial
- post hoc Bayesian re-analysis
- normal-normal Bayesian framework
- weakly informative prior on the log relative risk (RR) scale
- analyses under multiple priors
Authors' conclusion
Complete revascularization provides a high probability of clinically meaningful benefit in NSTEMI patients with MVD, primarily through reductions in nonfatal MI and repeat revascularization.
Study context
- Population
- Patients presenting with non-ST-elevation myocardial infarction (NSTEMI) and multivessel disease (MVD)randomized · complete 240 · culprit-only 238
- Participants
- 478 patients
- Comparison
- complete revascularization vs culprit-only
- completen = 240
- culprit-onlyn = 238
- Primary endpoint
- composite endpoint of:
- All-cause death
- Nonfatal myocardial infarction (MI)
- Repeat revascularization
- Stroke
Primary result
As reported in the abstract
complete vs culprit-onlyPosterior median RR (95% CI)
credible interval [CrI]
0.41(0.22–0.76)
complete vs culprit-onlyARD (95% CI)
credible interval
−7.9%(−10.4% to −3.2%)
- probability of any benefit
- 99.8%
- probability of meeting the minimal clinically important difference (MCID)
- 91.2%
Secondary outcomes
| Outcome | ARD (95% CI) | |
|---|---|---|
| repeat revascularization · credible interval | −8.3% (−10.0% to −4.5%) | |
| nonfatal MI · credible interval | −2.8% (−4.2% to 0.9%) | |
| −15−10−505Difference (linear scale) |
- repeat revascularization — probability of clinically relevant benefit
- > 99.9%
- nonfatal myocardial infarction (MI) — probability of benefit
- 94.8%
robustness across priors
- Results were consistent across all priors
Original publication
Probabilities of treatment effects in complete or culprit-only revascularization for NSTEMI: A Bayesian re-analysis of the SLIM trial. Am Heart J. Published 5 February 2026. doi:10.1016/j.ahj.2026.107369
Summarised from the published abstract; every number is checked against it