Prognosis of acute coronary syndrome stratified by cancer type and status - a nationwide cohort study
Authors' conclusion
Active- and non-active cancers were associated with an increased 1-year all-cause mortality compared with patients with history of cancer and no cancer. Cardiovascular disease was the leading cause of death; notably CAG was less frequently performed in cancer patients.
Study context
- Population
- Patients with first-time acute coronary syndrome (ACS), Denmark, 2000–2018; breast, gastrointestinal and lung cancer
- Participants
- 150,478 / 2,370 / 2,712 / 1,704
- Exposure
- Cancer type and status vs no cancer
- No cancern = 150,478reference
- History of cancern = 2,370
- Non-active cancern = 2,712
- Active cancern = 1,704
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsDanish nationwide registers
- Danish nationwide registers
Main finding
As reported in the abstract
1-year all-cause mortality
Each group vs no cancerHazard ratio (95% CI)
Active breast cancer
1.71(1.44–2.02)
Active gastrointestinal cancer
2.47(2.23–2.73)
Active lung cancer
4.22(3.87–4.60)
Observational data: associations, not effects.
Further findings
- Coronary angiography (coronary angiograms (CAG)) · 30 days — No cancer
- 77%
- Coronary angiography (CAG): Active breast cancer 43%
- Coronary angiography (CAG): Active gastrointestinal cancer 43%
- Coronary angiography (CAG): Active lung cancer 31%
Cause of death · 1 year
- CVD was the leading cause of death in all patients
Original publication
Prognosis of acute coronary syndrome stratified by cancer type and status - a nationwide cohort study. Am Heart J. Published 9 November 2022. doi:10.
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