Acute cardiac care & resuscitation
Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis
Authors' conclusion
The findings of this review confirm several clinical concepts wellestablished in the cardiac arrest literature and their applicability to the patient for whom ECPR is considered - that is, the impact of pre-existing patient factors, the benefit of timely and effective CPR, as well as the prognostic importance of minimizing low-flow time.
Study context
- Population
- Adults requiring extracorporeal cardiopulmonary resuscitation (ECPR) for refractory out-of-hospital cardiac arrest (OHCA)
- Participants
- 7,397 adults · 29 studies
- Comparison
- Pre-ECPR prognostic factors and favourable functional outcome
- Outcome
- Survival with favourable functional outcome
Methodological detailsMedline and Embase searched to February 28, 2023, Risk of bias by QUIPS; certainty by GRADE
- Medline and Embase searched to February 28, 2023
- Risk of bias by QUIPS; certainty by GRADE
Pooled result
As reported in the abstract
Survival with favourable functional outcome:
- Factors with moderate
- High certainty
Odds ratio (95% CI)
Younger age
2.13(1.52–2.99)
Female sex
1.37(1.11–1.70)
Shockable rhythm
2.79(2.04–3.80)
Witnessed arrest
1.68(1.16–2.42)
Bystander CPR
1.55(1.19–2.01)
Return of spontaneous circulation
2.81(2.19–3.61)
- Shorter time to cannulation · per 10 minutes
- OR 1.14 (95% CI 1.17–1.69)
Original publication
Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. Published 18 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it