Heart failure & cardiomyopathies
Prognostic Factors of Readmission and Mortality After First Heart Failure Hospitalization: Results from EPICAL2 Cohort
Authors' conclusion
Regardless of the prognostic state considered, we showed that comorbidities are of critical prognostic value in a real-world cohort of incident HF cases.
Study context
- Population
- Incident cases of first acute heart failure (HF) hospitalization alive at discharge (EPICAL2 cohort)
- Participants
- 451 cases
- Outcome
- First readmission and mortality before and after readmission (prognostic factors)
- Follow-up
- Within the year after discharge
Methodological detailsobservational, multicentre, illness-death model
- Observational
- Multicentre
- Illness-death model
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
Charlson index ≥ 8first readmission
1.6(1.1–2.3)
P = 0.011Charlson index ≥ 8mortality before readmission
4.2(1.2–14.8)
P = 0.025Low BPmortality before readmission
12.2(1.9–79.6)
P = 0.009High BPmortality before readmission
6.9(1.3–36.4)
P = 0.023Recommended dual or triple HF therapy at dischargemortality before readmission
0.2(0.1–0.7)
P = 0.014Charlson index ≥ 8mortality after readmission
2.4(1.1–5.6)
P = 0.037Time to first readmission (per 30 days additional)mortality after readmission
1.2(1.1–1.4)
P = 0.007Per 30 days additional, as printed
- Deaths before readmission
- 23 (5.1%)
- First readmissions
- 270 (59.9%)
- Readmissions followed by death of any cause
- 60 (22.2%)
Observational data: associations, not effects.
Original publication
Prognostic Factors of Readmission and Mortality After First Heart Failure Hospitalization: Results from EPICAL2 Cohort. ESC Heart Fail. Published 8 December 2022. doi:10.
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