Heart failure & cardiomyopathies
The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction
Authors' conclusion
We identified 5 protein biomarkers of new-onset HFpEF representing pathways of inflammation, cardiac stress, and vascular stiffness, which partly overlapped with HFrEF. We found 14 biomarkers associated with new-onset HFrEF, with some distinct associations including myeloperoxidase, resistin, and paraoxanase-1.
Study context
- Population
- Framingham Heart Study participants (mean age 49 years; 54% women)
- Participants
- 7,038 participants
- Exposure
- 71 protein biomarkers and incident heart failure with preserved ejection fraction (HFpEF) vs heart failure with reduced ejection fraction (HFrEF)
- Outcome
- Incident HFpEF vs HFrEF (LVEF ≥ vs <50%)
Methodological detailsmultivariable Cox models
- Multivariable Cox models
Main finding
As reported in the abstract
Biomarkers associated with incident HFpEF (false discovery rate q<0.05)
- NT-proBNP, HR (95% CI 1.52-2.99), P<0.001
- 2.13
- Growth differentiation factor-15, HR (95% CI 1.32-2.12), P<0.001
- 1.67
- Adrenomedullin, HR (95% CI 1.23-2.04), P<0.001
- 1.58
- Uncarboxylated matrix Gla protein, HR (95% CI 1.23-1.95), P<0.001
- 1.55
- C-reactive protein, HR (95% CI 1.17-1.83), P=0.001
- 1.46
Observational data: associations, not effects.
Further findings
- Biomarkers associated with incident HFrEF (multivariable P<0.001, q<0.05 for all)
- 14
- Biomarkers associated with both HF subtypes (NT-proBNP, growth differentiation factor-15, C-reactive protein)
- 3
- Myeloperoxidase, resistin and paraoxanase-1 more strongly associated with HFrEF than HFpEF when compared directly
Original publication
The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction. Circ Heart Fail. Published 8 December 2022. doi:10.
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